Prevalence of FVL and PG 20210 A
نویسندگان
چکیده
prevalence of the thrombosis in the childhood increases in recent years. In adulthood, incidence of thrombosis is 1% and in childhood the incidence is 1/100,000 per year.1 In addition to its increasing prevalence in the childhood, as thrombosis is an important reason in the childhood morbidity and mortality, the studies on thrombosis gradually increase. It is known that the general mutations in factor V Leiden (FVL) and prothrombin gene (PG) 20210A genes increase the risk of venous thrombosis (VT). Factor V Leiden mutation is the A
منابع مشابه
Frequency and association of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR with deep vein thrombosis in the population of Bosnia and Herzegovina
The 1691 (G>A) factor V Leiden (FVL) and 20210 (G>A) prothrombin (PT) mutations are the two most common genetic risk factors in venous thromboembolism. The 677 (C>T) methylene tetrahydrofolate reductase (MTHFR) mutation is the most frequently mentioned as an independent genetic risk factor for venous thromboembolism. As there are limited published data on the prevalence of the 1691, 20210 and 6...
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We assessed the effect of a recently described mutation in the MTHFR gene (1298 A --> C) on the risk of deep venous thrombosis (DVT) by determining its prevalence in 190 patients with verified DVT and in age-, race- and gender-matched controls. MTHFR 1298 A --> C was found in 42.1% of patients and in 41.1% of controls. The OR for venous thrombosis was 1.07 (95% CI 0.70-1.65) for heterozygotes a...
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The prevalence of hereditary thrombotic risk factors shows marked ethnic and geographic variations. Hereditary disorders predisposing for thrombosis are not only antithrombin, protein C and protein S deficiencies, but also hereditary defects such as factor V 1691 G-A (Leiden) (FVL) and prothrombin 20210 G-A mutations [1,2]. FVL causes activated protein C resistance and is the most common thromb...
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